A scientific workshop sponsored by the world health organization the us public health service and the national institute for biological standards and control london was held in bethesda md usa on 13 and 14 november 1984 to review progress in research relevant to the development of genetically and antigenically modified vaccinia viruses as live vaccines for human and veterinary use. Vaccinia viruses re engineered to express foreign genes are robust vectors for production of recombinant proteins vaccinia viruses have been engineered to express immunizing antigens of herpesvirus hepatitis b rabies influenza human immunodeficiency virus hiv and other viruses figure 1 an electron micrograph of a vaccinia virus. Vaccinia viruses re engineered to express foreign genes are robust vectors for production of recombinant proteins the vaccinia viruses have been engineered to express immunizing antigens of influenza hepatitis b rabies herpes virus hiv and other viruses recombinant vaccinia viruses have been produced from different vaccinia virus strains. Vaccinia viruses engineered to express foreign genes are powerful vectors for production of recombinant proteins originating from highly efficacious vaccines securing world wide eradication of smallpox the most appealing use of vaccinia vectors is to serve as vaccine delivery system for heterologous antigens. B5 deficient vaccinia virus as a vaccine vector for the expression of a foreign antigen in vaccinia immune animals recombinant vaccinia viruses have shown promise as vaccine vectors however their effectiveness is markedly reduced by pre existing anti vaccinia immunity
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